Comprehensive Clinical Science Subject Exam - Content Outline
The Comprehensive Clinical Science Examination is a general, integrated achievement test covering material typically learned during core clinical clerkships. The exam reflects content coverage on USMLE Step 2.
Systems
- General Principles, Including Normal Age-Related Findings and Care of the Well Patient (1%–5%)
- Immune System (1%–5%)
- Blood & Lymphoreticular System (5%–10%)
- Behavioral Health (5%–10%)
- Nervous System & Special Senses (5%–10%)
- Skin & Subcutaneous Tissue (1%–5%)
- Musculoskeletal System (5%–10%)
- Cardiovascular System (5%–10%)
- Respiratory System (5%–10%)
- Gastrointestinal System (5%–10%)
- Renal & Urinary System (1%–5%)
- Pregnancy, Childbirth, & the Puerperium (5%–10%)
- Female Reproductive System & Breast (5%–10%)
- Male Reproductive System (1%–5%)
- Endocrine System (5%–10%)
- Multisystem Processes & Disorders (5%–10%)
- Biostatistics, Epidemiology/Population Health, & Interpretation of the Medical Lit. (1%–5%)
- Social Sciences, Incl. Medical Ethics, Professionalism, Systems-based Practice, & Patient Safety (10%–15%)
Physician Task
- Diagnosis: Knowledge Pertaining to Diagnostic Studies, Diagnosis, & Patient Outcomes (40%–50%)
- Patient Care: Health Maintenance (10%–20%)
- Patient Care: Pharmacotherapy, Intervention, & Management (40%–50%)

