RESEARCH LIBRARY

UT Electronic Theses and Dissertations

Using Monte Carlo simulation, the current study examines the performance of three IV estimators and two conventional estimators in recovering the CATE and CATE heterogeneity under simulation conditions that resemble multisite trials of well-known educational programs.

Qual Life Res 27, 1711–1720 (2018)

The US Food and Drug Administration (FDA), as part of its regulatory mission, is charged with determining whether a clinical outcome assessment (COA) is “fit for purpose” when used in clinical trials to support drug approval and product labeling. This paper provides a review (and some commentary) on the current state of affairs in COA development/evaluation/use with a focus on one aspect: How do you know you are measuring the right thing? In the psychometric literature, this concept is referred to broadly as validity and has itself evolved over many years of research and application.